The Cover of the October
International Journal of Cancer
displays a picture of the 3D omental
metastasis model created by the Lengyel Lab
Selected References
Sawada K., Radjabi A.R., Shinomiya N., Kistner E., Kenny H., Salgia R., Becker A.R., Turkyilmaz M.A., Salgia R., Yamada S.D., Vande Woude G.F., Tretiakova M.S., and Lengyel E. C-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Research 2007; 67(4):1670-1680 Abstract
Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by
targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008 Apr 1;22(7):894-907. Abstract
Sawada K, Mitra AK, Radjabi AR, Bhaskar V, Kistner EO, Tretiakova M, Jagadeeswaran S, Montag A, Becker A, Kenny HA, Peter ME, Ramakrishnan V, Yamada SD, Lengyel E. Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin,
which is a therapeutic target. Cancer Res 2008 Apr 1;68(7):2329-39. Abstract
Hilary A. Kenny, Swayamjot Kaur, Lisa M. Coussens, and Ernst Lengyel.The initial steps of ovarian cancer cell metastasis are mediated by MMP-2
cleavage of vitronectin and fibronectin. J Clin Invest. Published online 2008 March 13. doi: 10.1172/JCI33775 Full text from PubMed Central See related press release here
Radjabi AR, Sawada K, Jagadeeswaran S, Eichbichler A, Kenny HA, Montag A, Bruno K, Lengyel E.Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta -1 integrin on the cell surface. J Biol Chem. 2007 Nov 29; Abstract
Shell S., Park, S.M., Radjabi A.R., Schickel R., Kistner E., Jewell D.A., Feig C., Lengyel E., and Peter M. Let-7 expression defines two differentiation stages of cancer. Proc Nat Acad. Sci., 2007, 104 (27) 11400-11405 - Lengyel and Peter share last authorship. Abstract
Kenny H.A., Krausz T., Yamada S.D., and Lengyel E. Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum. International Journal of Cancer, 2007, 121(7):1463-72. This article provided the issue’s featured cover art. Abstract Cover
Sawada K., Radjabi A.R., Shinomiya N., Kistner E., Kenny H., Salgia R., Becker A.R., Turkyilmaz M.A., Salgia R., Yamada S.D., Vande Woude G.F., Tretiakova M.S., and Lengyel E. C-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Res 2007; 67(4):1670-9 . Abstract
Lengyel E., Prechtel D., Resau J., Gauger K., Welk A., Lindemann K., Salanti G., Richter T., Vande Woude GF, and Harbeck N. C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu. 2005, International Journal of Cancer, Feb 10, 113(4), 678-82 Abstract
Hapke S., Gawaz M., Reuning U., Köhler J., Dehne K., Marshall J., Graeff H., Schmitt M., and Lengyel E. beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter. Molecular and Cellular Biology, 2001, 21 (6), 2118-2132 Abstract
Schmalfeldt B., Prechtel D., Härthing K., Späthe K., Rutke S., Berger U., Schmitt M., Kuhn W., and Lengyel E. Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-typeplasminogen activator is associated with progression from benign to advanced ovarian cancer Clincal Cancer Research 2001, 7 (8), 2396-2404 Abstract
Schnelzer A., Prechtel D., Knaus U., Dehne K., Gerhard M., Harbeck N., Schmitt M., and Lengyel E. Rac1 in human breast cancer: Overexpression, mutation analysis, and characterization of a new Rac1 isoform, Rac1b. Oncogene 2000, 19 (26), 3013-3020 Abstract
Hannke-Lohmann A., Pildner von Steinburg S., Dehne K., Benard V., Kolben M., and Lengyel E.Downregulation of the mitogen-activated protein kinase signaling pathway in the placentas of women with preeclampsia.. Obstetrics and Gynecology 2000, 96 (4), 582-587 Abstract
Ried S., Jäger C., Jeffers M., Vande Woude G., Graeff H., Schmitt M., and Lengyel E. Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor (HGF/SF). Journal of Biological Chemistry 1999, 274, 16377-16386 Abstract
Lengyel E., Wang H., Gum R., Simon C., Wang Y. and Boyd D.Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade. Oncogene 1997, 14, 2563-2574 Abstract
Lengyel E., Gum R., Juarez J., Sato H., and Boyd D. Induction of Mr 92,000 Type IV collagenase expression in a squamous cell carcinoma cell line by fibrobasts. Cancer Research 1995, 55, 963-967 Abstract